IP Indian Journal of Orthodontics and Dentofacial Research
Official Publication of Khyati Education And Research Foundation
Official Publication of Khyati Education And Research Foundation
Print ISSN: 2581-9356
Online ISSN: 2581-9364
CODEN : IIJOCV
IP Indian Journal of Orthodontics and Dentofacial Research (IJODR) open access, peer-reviewed quarterly journal publishing since 2015 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the more...Review Article
Author Details :
Volume : 6, Issue : 3, Year : 2020
Article Page : 125-129
https://doi.org/10.18231/j.ijodr.2020.026
Abstract
Craniofacial development is a sophisticated process which has multiple genetic and epigenetic factors involved. Disturbance in the developmental process can cause morphologic and functional defects, which may also affect the psychological health of the individual. It is imperative for orthodontists to have a thorough knowledge about the growth of the face in general and of the maxilla and mandible in particular, to help modify growth and treat the skeletal malocclusions. Multiple genes have been implicated in the growth of the craniofacial complex, growth hormone receptor gene (GHR) being one of them. Growth hormone plays an important role in the post-natal development of an organism, both skeletal and soft tissue growth. Mutation of its receptor will affect the expression of the gene, and in turn influence the growth. Studies have shown that polymorphisms in the GHR gene receptors affect the morphology of the maxillomandibular skeleton. This article is a review about the polymorphisms of the GHR gene which affect the facial skeletal pattern.
Keywords: Growth hormone receptor gene, Craniofacial morphology, Skeletal malocclusion, Growth hormone.
How to cite : Kathijathul Hidhaya S, Tripathi T, Kalra S , Rai P, Kanase A, Association between growth hormone receptor gene polymorphism and craniofacial morphology – A review. IP Indian J Orthod Dentofacial Res 2020;6(3):125-129
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