Invisalign is a series of removable clear appliances to effect tooth movement in orthodontic therapy carried through ‘An Invisible’ way of straightening teeth without using antiquated metallic braces and wires. It instead adopts a method of fabricating clear custom fabricated aligners designed to gradually and sequentially move teeth to their desired positions using a computer assisted technology. Also called as “Aligners” or as "Repositioners". The main aim of this study is to search the current literature regarding the Invisalign system. This systematic review will provide a more up-to-date understanding of this system, as well, an evaluation of the indications, contra-indications and case selection using Invisalign can also be conducted.